The scientists conducted a more detailed analysis of 200 additional copies of fibroids and identified specific mutation, typical for 70% of the studied tumors.
As a result, the detected mutation disrupted the structure of the protein – gene product, which is known to play an important role in transcription (RNA synthesis using DNA as template).
Mutations detected pattern indicates that it is a bug in the gene leads to the formation of the majority of fibroids.
Scientists believe that the fact that such a high percentage of fibroids so peculiar characteristic mutation will allow further work to develop new therapeutic techniques aimed at restoring normal functioning.
Commenting on the findings, head of research group Professor Laurie Aaltonneo writes: “This is a giant step toward understanding the causes of fibroids, but only a small step to the creation of targeted therapy.
Nevertheless, we hope that this is the beginning of a large and successful way. ”
What are uterine fibroids – primarily a benign tumor? The peak incidence begins to 35 years and among women be nearly 40%. But recently, this disease is detected in younger women.
Fibroids have several types:
• Tumor, located in the walls of the uterus layers;
• Tumor grows abdominally – subserous.
Reasons that can develop uterine fibroids:
• Hormonal background;
• Failure of menstruation;
• Heavy menstrual discharge that lead to fluctuations in hormone;
• Genetic predisposition;
• High blood pressure;
• Sexual disharmony, mainly starting with 25 years;
• Relaxed lifestyle inactivity.